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In the context of FPN deficiency or inadequate expression, the cells cannot efficiently export iron, resulting in continued accumulation of free iron and further enhancing the detrimental effects of ferroptosis

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It is also worth investigating whether the supplementation of with I 2 -Q 10 restores respiratory function in a CoQ-deficient cell culture model, as some CoQ derivatives suffer from a loss of function upon modification of the tail (e.g., Mito-Q)

also see Jean et al